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Common Side Effects Nausea Diarrhea Vomiting Constipation Stomach pain Appetite reduction Headache Serious Side Effects (less common) Pancreatitis Gallbladder issues Potential kidney injury Severe allergic reactions Vision changes in type 2 diabetes patients Elevated heart rate An essential warning accompanies oral semaglutide regarding thyroid C-cell tumors observed in animal studies

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Studies have suggested that the N-terminal residues His7, Gly10, Phe12, Thr13 and Asp15 are essential for interaction with the GLP-1 receptor, as substituting these residues with L-Ala leads to a severe loss of affinity for its receptor [43]

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Uruska A, Araszkiewicz A, Uruski P, Zozulinska-Ziolkiewicz D (2014) Higher risk of microvascular complications in smokers with type 1 diabetes despite intensive insulin therapy