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And unfortunately, this combination is not uncommon on GLP-1 medications, particularly during the first few weeks of treatment or after dose increases

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Physiologically, leptin activates neurons in the POA to activate the downstream effector neurons in the nucleus raphe pallidus (RPa) via a projection from POA to DMH, enhancing the sympathetic activity of brown adipose tissue (BAT) and thermogenesis [22], [23], [24]

Because these medications reduce appetite and slow stomach emptying, the focus shifts from simply eating less to making every meal count nutritionally