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When compared head-to-head with semaglutide in the SURPASS 2 trial, nausea was reported in 1722% of patients who received tirzepatide, and in 18% who received semaglutide
To increase the stability of GLP-1R, the fusion protein rubredoxin was inserted into intracellular loop 2 (ICL2) of GLP-1R between positions 257 to 262 and 11 mutations were introduced
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This shift is connected to the body metabolizing more fat, but it may be important in terms of safety, particularly for individuals with comorbidities
