glp 1 synergizer How GLP-1 medications are transforming diabetes and weight loss treatment GLP-1 Receptor Agonist Shortage: Challenges

10.1007/s00125-010-1874-x [DOI] [PMC free article] [PubMed] [Google Scholar] 8.Smith KJ et al (2013) Association of diabetes with anxiety: a systematic review and meta-analysis

figure 1

Ortega FB, Lavie CJ, Blair SN

Such limitations prompted the development of second-generation medicines capable of sustaining stable drug concentrations with reduced dose frequency, hence enhancing both effectiveness and tolerance characteristics

This is important because GLP-1 drugs were originally designed to have a long half-life in blood to maximise their efficacy in the treatment of diabetes which prevents them from entering the brain (Hlscher)