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Confounding by obesity (which itself increases autoimmune risk)

This review aims to summarize the findings from CVOTs of GLP-1RAs, explore the latest data on dual and tri-agonist therapies, and delve into potential mechanisms contributing to their cardioprotective effects

In addition to stimulating the GLP-1 receptor, tirzepatide also activates the GIP receptor

However, important limitations exist in the current evidence: Most studies have been relatively small with short follow-up periods Many participants had concurrent obesity, making it difficult to separate weight loss effects from direct effects on binge eating behaviour Long-term efficacy and safety data specifically for binge eating disorder are lacking The psychological and behavioural components of BED may require interventions beyond pharmacological appetite suppression There is no official link established by regulatory bodies between GLP-1 agonists and binge eating disorder treatment

Primary care physicians manage the vast majority of patients with obesity and type 2 diabetes, and many are more comfortable prescribing oral medications than injectable peptides