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[10] When increased intra-abdominal pressure is repeatedly applied during defecation, it can cause swelling and inflammation of the vascular cushions in the anal canal, leading to symptomatic haemorrhoids

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It is an investigational molecule under phase 3 evaluation in Eli Lillys TRIUMPH program, which spans obesity, obesity with type 2 diabetes, and obesity with established cardiovascular disease, among other readouts but not, at the registrational level, PCOS