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In PIONEER 6, oral semaglutide was associated with a reduction of 45% in total cholesterol and LDL-C levels and 12% in triglyceride levels from baseline [58]

Additionally, a meta-analysis conducted in 2012 revealed a potential pathogenic effect of a fatty diet in the development of pancreatic cancer [21]

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SGLT2 inhibitors have varying eGFR thresholds depending on the specific agent and indication

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