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The NIHR Innovation Observatory states that it has no Marketing Authorisation in the EU/UK and remains in phase III development , which means it should be understood as an investigational medicine rather than a treatment clinicians can routinely deploy in standard practice (NIHR Innovation Observatory briefing on retatrutide)

Continuous low-dose therapy may be more cost-effective and metabolically stable than cycling on and off, especially if genetic testing shows strong GLP-1 pathway sensitivity

Different weight effects: Semaglutide usually has a larger appetite and weight effect than metformin

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