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Semaglutide activates GLP-1 receptors only, while tirzepatide is a dual GIP/GLP-1 receptor agonist, activating two complementary pathways involved in blood sugar regulation and appetite control
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[1] In STEP UP trial data, average weight loss at 72 weeks was greater with semaglutide 7.2mg than with 2.4mg, but trial averages do not predict an individual result
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