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Lebrun LJ, Lenaerts K, Kiers D, Pais de Barros J-P, Le Guern N, Plesnik J, Thomas C, Bourgeois T, Dejong CHC, Kox M, Hundscheid IHR, Khan NA, Mandard S, Deckert V, Pickkers P, Drucker DJ, Lagrost L, Grober J

Y = years, mg = milligrams, mcg = micrograms, n = number of subjects, BMI = body mass index, NASH = non-alcoholic steatohepatitis, NAFLD = non-alcoholic fatty liver disease, kg = kilograms, ALT = alanine aminotransferase, AST = aspartate transaminase, LFF = liver fat fraction, T2DM = type 2 diabetes mellitus, PCOS = polycystic ovary syndrome, NR = not reported

Hyperglycemia alters both extracellular and intracellular metabolism, leading to effects such as glomerular hyperfiltration (4), oxidative stress (5), the accumulation of advanced glycation end products (AGEs) (6), the activation of protein kinase C (7), abnormal polyol metabolism (8), the overexpression of transforming growth factor- (TGF-) (9) and inflammation

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Benefits and harms of once-weekly glucagon-like peptide-1 receptor agonist treatments a systematic review and network meta-analysis comparative clinical profiles of once-weekly GLP-1RAs