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Most tirzepatide injection site reactions are mild to moderate and resolve spontaneously within 2-3 days without requiring treatment

Common side effects may include: Nausea

This reduces total injection frequency and makes the protocol easier to maintain

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Depressive symptoms and increased anxiety due to diabetes-related distress (i.e., the emotional and psychological burden associated with managing diabetes [140] are associated with poor self-care behaviors and worse intermediate and long-term health outcomes [218]