glp-1 agonist therapy glp-1_analogs [TUSOM GLP-1 Drugs & What They

doi: 10.1007/s11357-011-9303-8 183 YoshinoYIshisakaMTsujiiSShimazawaMHaraH

Incretins : Hormones released from the small intestine when you eat

117 Interestingly, glucagon also exerts insulinotropic effects on islet beta-cells, and this is likely to allow for tissues to uptake glucose and fat once glucagon has induced their catabolism from nutrient storage (as tissues such as skeletal muscle rely on insulin for nutrient uptake from circulation), or the insulinotropic effects of glucagon could simply serve as a feedback inhibition mechanism

None of the AEs led to premature treatment discontinuation

Encouraged by such results, Saxenda expanded its indication to adolescent patients aged 12-18 with BMI equivalent to 30kg/ adults and weighing 60kg or more in December 2021