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The GLP-1 connection is indirect

Although our data align with the notion that inhibiting NMDA receptor signalling in the hypothalamus decreases food intake and body weight 8,40 , earlier studies have demonstrated that NMDA receptor antagonism in the brainstem attenuates vagus-mediated meal-related satiety 6,7,42

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Subsequently, YGD has been demonstrated to produce a robust acute effect on caloric intake and meal duration, suggesting that YGD strengthens within-meal satiation, an effect that may be mediated by the previously reported changes in gastric emptying [67]