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Mechanistic Cause: Muscle loss is largely driven by caloric restriction and lack of mechanical stimulus, not a direct toxic effect of the drug on muscle fibers

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By rough analogy, measuring mobility and discomfort after shoulder surgery is entirely different from measuring response to an antidepressant or to a psychotherapeutic, because in psych, the rating refers to and influences the thing being rated

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Menon T, Lee S, Gong XY, et al

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Digestion slows

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9 Consequently, lifestyle interventions frequently require supplementation with pharmacological treatments to achieve more substantial weight loss outcomes

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