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The lack of a relationship between energy intake and changes in gastric emptying and intragastric distribution in individuals treated with lixisenatide is consistent with the concept that effects on appetite are primarily centrally mediated (27)

After sustained exposure to long-acting GLP-1RAs, tachyphylaxis for the effects on gastric emptying has been observed (19)

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Next-Generation Oral Small-Molecule GLP-1s Unlocking Primary-Care and Emerging-Market Volume Orforglipron, GSBR-1290, and VK2735 demonstrated double-digit weight-loss efficacy in Phase 2 studies without injection-related barriers, attracting strong interest from primary-care physicians