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"If someone is experiencing any side effects while taking any Lilly medication, we encourage them to speak with their healthcare provider." Users can also call the The Lilly Answers Center at 1-800-LillyRx

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However, berberine also lowers blood sugar by improving insulin sensitivity and inhibiting glucose production in the liver

Metformin, the current first-line treatment in T2DM, has an unclear antidepressant effect [166] despite identified direct mechanisms and pleiotropic effects, including inhibition of angiotensin II and NF-B factor, normalization of gut microbiota, and intestinal permeabilization, and in vivo experimental data [167] supporting its potential benefits