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doi: 10.1021/jm9909645 10 GlaesnerWVickAMMillicanREllisBTschangSHTianYet al

In addition to the neurocentric context highlighted earlier, it is apparent that novel experimental paradigms are needed to fully establish the therapeutic relevance of GLP-1RAs in neurodegenerative diseases

Adiponectin mediates these effects by promoting the storage of triglyceride (TG) in white adipose tissue through stimulation of lipoprotein lipase and by increasing muscle fat oxidation and glucose uptake by stimulation of 5 adenosine monophosphate-activated protein kinase (AMPK) in muscle (Figure 3) [40]

A WEIGHT-LOSS FOCUSED GLP-1 DEVICE SHOULD EMPHASISE PROGRESSION AND MOVEMENT TOWARDS A GOAL, WHICH MAY DIFFER FROM DESIGNS FOR T2D USERS. A weight-loss focused GLP-1 device should emphasise progression and movement towards a goal, which may differ from designs for T2D users

However, the market faces constraints such as high treatment costs, limited access in lower-income regions, and gastrointestinal side effects which may limit long-term adherence