once-weekly semaglutide in persons with obesity and knee osteoarthritis Ozempic (semaglutide) is a medication used for the management of diabetes obesity. This study evaluated the effect of Ozempic on pain obese patients osteoarthritis. Swipe above for what GLP-1s and Knee Osteoarthritis -

Cho et al., 2019)

If you are losing weight consistently at 8mg with manageable sides, there may be no need to push to 12mg

These complementary compounds work synergistically with semaglutide, but only if the semaglutide itself is delivering its full potency

PIONEER 4 adverse events vs liraglutide 1.8 mg 5 Comparator AE rates are not an adequate basis for comparison of safety between products Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice Data are n (%)

Nature 394 , 3538