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Industry Implications CDMO & Pen Makers: Shailys expansion signals profitable growth in device manufacturing Generic Drug Makers: Need to scale peptide production and align launch timelines with pen availability Global Access Shift: Pen-device supply becomes a bottleneck unless proactively expanded Recommended Actions for Pharma Stakeholders 1

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Conclusions/interpretation These results suggest that CB1R could be an interesting target for type 1 diabetes while highlighting the regulatory mechanisms of insulitis