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Semaglutide is an incretin mimetic that increases insulin secretion , [21] and berberine usually increases it as well

A 4-week trial of once-weekly administration of a long-acting FGF21 analog, PF-05231023, increased systolic and diastolic blood pressure and heart rate while reducing triglycerides without changing body weight in obese human subjects with hypertriglyceridemia with or without T2D [37]

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Therefore, patients who are more predisposed to fractures can benefit significantly from these medications, making DPP-4 inhibitors a very appealing therapeutic option for the elderly [26]