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[2] Wegovy is approved in the UK for weight loss and long-term weight management in adults with: A BMI of 30 or higher A BMI of 27 or higher with at least one weight-related health condition (such as high blood pressure or sleep apnea) Ozempic's use in diabetes treatment Ozempic is approved for managing type 2 diabetes, with the added benefit of weight loss as a secondary outcome

References Rat anabolic/nitrogen retention dosing including des(13) IGF1 ~1.08 mg/kg/day Nephrectomized rat model des(13) IGF1 0.9 mg/kg/day for 7 days Des(13) IGF1 additional rat dosing example 1.2 mg/kg/day Invitro concentration range example 6.753 nM Biodistribution/clearance considerations for labeled des(13) IGF1 Research Resources Follistatin 344 (FS344) Human dosage only (what's actually in clinical studies) Quickstart Highlights Compound (Human clinical form): rAAV1.CMV.huFS344 (AAV1mediated follistatin FS344 gene transfer) Route used in trials: Intramuscular (IM) injections into targeted muscles How dosing is expressed: vector genomes per kilogram (vg/kg) (not mg) Human trial doses reported: 6 10 vg/kg and 1.2 10 vg/kg (BMD cohorts)

Since mid-July, the number of filed cases has more than quadrupled