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Insurers said they had to withdraw coverage because the pricey medicines overwhelmed their budgets, forcing patients to either go off the drugs or pay for them out of pocket.

The study demonstrates that quantitative target engagement of dual agonists can be assessed by PET.

However, further research is needed to fully understand how these therapies exert their effect on body weight and in the last section we cover open questions about the potential mechanisms of multiagonist drugs, and the understanding of how gutbrain communication can be leveraged to achieve sustained body weight loss without adverse effects.

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