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GLP-1 slows stomach emptying slightly, which may delay thyroid medication absorption if taken together

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Analytical liquid phase analysis was carried out to the reaction mixture (using liquid phase conditions: adopt Agilent 1260 system to carry out liquid phase analysis, wavelength 214nm, chromatographic column is the reverse phase C18 column of 4.6 * 250mm, column temperature is 35 , mobile phase is 0.1% Water (phase A) and 0.1% acetonitrile (phase B), the flow rate is 1mL / min, gradient: B%: 30%-45%, 0-20min.), the results

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This adaptation period is why dose escalation follows a gradual schedule rather than jumping to full strength immediately