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Where it works: Adipose tissue (fat cells): Reduces inflammation and may improve fat metabolism Pancreas: Works alongside GLP-1 to enhance insulin secretion Brain: May contribute to appetite regulation (research ongoing) Weight loss contribution: When GIP is added to GLP-1 (as in tirzepatide), weight loss increases from ~15% to ~22%

Liraglutide Liraglutide is a prescription drug used to treat type 2 diabetes and obesity, both of which are risk factors for Alzheimer's disease

The obtained good 2D classes were used for template-based automatic particle picking, and false positives or bad particles were subsequently eliminated over two rounds of 2D classification, resulting in 9101 selected particles

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Supplementary information This file contains Supplementary Text and Data, 2 Supplementary Tables and Supplementary references