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That does not make them ineffective

Based on the strength of evidence and safety boundaries, a more rational clinical positioning is to reserve GLP-1RAs as an individualized tool for intensive metabolic optimization prior to ART in refractory PCOS individuals with high BMI and prior weight-loss failure

Patient-specific factors Choice of GLP-1 medication also depends on certain factors like the presence of renal or hepatic issues, history of severe gastrointestinal side effects (gallstones, severe stomach pain, and pancreatitis), blood sugar levels, and weight loss goals

It cannot be used for people with Type 1 Diabetes (unless from specialist endocrinology)

How long before I notice benefits for my fibromyalgia