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Furthermore, a national cohort study found that a notable percentage of patients (up to 10%) required revisional surgery within 5 years of follow-up [16]

Primary Handling editors: Jennifer Sargent and Jerome Staal, in collaboration with the Nature Medicine team Data availability Lilly provides access to all individual participant data collected during the trial, after anonymization, with the exception of pharmacokinetic or genetic data

The SELECT trial, published in 2023, enrolled 17,604 adults with overweight or obesity and established cardiovascular disease but without diabetes

In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]

Treating Facial Volume Loss With Fillers For patients who want to restore lost volume and droopy skin, and rejuvenate their appearance, dermal fillers offer a safe, effective, and non-surgical solution