glp-1 agonists weight loss mechanism Frontiers Weight Reduction with GLP-1 Agonists

Buteau from the University of Montreal in Quebec, Canada and colleagues, GLP-1 at physiological concentrations increased beta cell DNA synthesis that was independent of glucose

For the scenario of "Currently Available Treatment," research data suggests Tirzepatide may be more relevant

Mounjaro generally offers the strongest weight-loss results

Between these two, metformin is our first-line preference as it helps not only with antipsychotic-related weight gain but also with the metabolic side effects of antipsychotics (insulin resistance, fasting glucose, triglycerides, and hyperprolactinemia), earning it a recommendation from the APA for this purpose

Leveraging the natural effects of GLP-1, these agonists encourage weight loss through various pathways, including enhancing satiety and promoting better glycemic control