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However, these observational studies have inherent limitations, including potential residual confounding (as some registries lack complete data on important cancer risk factors like smoking), selection bias, and the challenge of detecting rare events

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Influenced by the work of Bayliss and Starling, Moore hypothesized that the intestinal mucosa membrane produces a substance of the nature of a hormone that decreases blood glucose via its stimulatory action on the pancreas [55]

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For years, the question of whether a daily pill could ever match the efficacy of a weekly injection was largely theoretical

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