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Another study, published in the American Journal of Ophthalmology, used health records from over 37 million people and found that GLP-1 drugs nearly doubled the five-year risk of developing optic nerve damage

doi: 10.1016/j.hjc.2018.11.008 43 Rico-FontalvoJReinaMSolerMJUnigarro-PalaciosMCastaeda-GonzlezJPQuinteroJJet al

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Consistent with our observation, the dual agonist Tirzepatide revealed reduced internalization upon binding to the receptor, the phenomenon is attributed to its limited ability to recruit beta-arrestin (41)