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, Stoffers, D
While Mounjaro has shown promising results, it is still a newer product with relatively limited market penetration compared to the more established options from Novo
In animal models, this alcohol-induced reward is characterized by activation of the mesolimbic dopamine system, and it can be studied in preclinical models that involve hyperlocomotion, dopamine release in the NAc, and reward in the conditioned place preference (CPP) paradigm (Sanchis-Segura and Spanagel, 2006)

Additionally, the positive outcomes of ongoing trials SURPASS-CVOT and SURMOUNT-MMO will provide definitive evidence regarding the cardiovascular safety and efficacy of tirzepatide compared to dulaglutide and reduction in morbiditiy and mortality in adults with obesity respectively
