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GLP-1R activation has also been shown to suppress FLS proliferation and inhibit the p38 mitogen-activated protein kinase/nuclear factor kappa B (NF-B) signaling pathway, leading to reduced inflammatory cytokine production and subsequent slowed tissue degradation[21]

In the end, the goal isnt to take the smallest dose possibleits to find the safest, most effective approach for lasting health

Relative to placebo, doses 0.75 mg of RG7697/NNC0090-2746 were associated with dose-dependent reductions in fasting and postprandial glucose levels and increased insulin sensitivity, with no effect on gastric emptying

Liberini CG, Koch-Laskowski K, Shaulson E, McGrath LE, Lipsky RK, Lhamo R, Ghidewon M, Ling T, Stein LM, Hayes MR

Note any side effects, their severity, and whether they are improving or worsening