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The real shift isnt just the molecule its usability

They weren't taking GLP-1s to shed fatthey were using it for blood sugar control

Xigduo XR is an effective treatment for Type 2 Diabetes

Finally, we demonstrate that in mice, both the efficacy and tolerability of GLP1R agonists vary with the phase of the estrous cycle, being highest during proestrus (when estrogen levels peak) and lowest in diestrus (low estrogen levels)
