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The Obesity Society convened a congressional briefing on Capitol Hill that featured three speakers who expressed concerns about the proliferation of compounded GLP-1s in the U.S

Patients with a history of pancreatitis should be carefully evaluated, as GLP-1 receptor agonists have been associated with acute pancreatitis in some cases

Consider staying at 7.5 mg if: You are losing 1 to 2 pounds per week consistently Appetite suppression is adequate to maintain a caloric deficit Side effects are minimal and manageable You are comfortable with the cost at this dose level Consider continuing to 10 mg if: Weight loss has plateaued for more than 3 weeks at 7.5 mg Appetite suppression has diminished significantly Your target weight is still far from current weight Side effects at 7.5 mg are mild and tolerable Many researchers use the troubleshooting guide to determine whether a dose increase is the right move or whether other factors like dietary compliance or sleep quality are affecting results

From there, your dose may increase gradually over time but theres no single right pace or target

Evidence-based weight loss