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These animal models have also explored whether G protein-coupled taste receptor expression is altered in obesity models, particularly in leptin-deficient ob/ob mice and diet-induced obesity models (122)

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Outlier studies found by visual examination of forest plots, excessive standardized mean differences, inconsistent measurement scales, or implausibly small variances were rigorously excluded from these analyses

Researchers who have studied AOD 9604 dosage protocols generally recommend morning administration before food intake for this reason

All experiments were performed in accordance with the guidelines established by the National Institute of Health Guide for the Care and Use of Laboratory Animals and approved by the University of Texas Institutional Animal Care and Use Committee