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When GLP-1 binds to its receptor, it amplifies the insulin signaling pathway, causing increased phosphorylation of insulin receptor substrates and activating the PI3K/Akt pathway, which ultimately results in enhanced glucose uptake, utilization within the liver, and reduced production of glucose (gluconeogenesis)

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However, this "delayed gastric emptying" poses a risk of pulmonary aspiration when patients are sedated for surgery or other procedures

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GLP-1 also suppresses appetite and gastric emptying [23]

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Sharkey L

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Regardless, constipation can contribute to UTIs, and it is well known that both GLP-1 and GLP-1/GIPs, such as tirzepatide, cause decreased GI motility as one of the ways they assist in weight reduction

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