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Frontiers in Neurology
The Tri-Agonist Mechanism Retatrutides tri-agonist mechanism targets three key receptors: GLP-1, GIP, and glucagon receptors, which complement each other to regulate blood sugar, body weight, and fat metabolism
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With respect to body weight, cotadutide at 200 g led to weight loss of 3.22 kg on average versus 3.33 kg with liraglutide, but the 300 g dose led to weight loss of 5.02 kg albeit with far higher gastrointestinal adverse event rates than liraglutide (85)
