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Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone
In contrast, recommendations for treatment selection in the second-line setting have been outlined in international guidelines, such as the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) guidelines, which inform choice of treatment according to an individuals CV and chronic kidney disease (CKD) risk [15]
Key features of retatrutide include: Acts as a triple agonist on GLP-1, GIP, and glucagon
[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Apperloo EM, Neuen BL, Fletcher RA, et al
Accessed April 22, 2026.
