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triple glp 1 gip glucagon receptor agonist Targeting GLP-1, & GCG in Obesity and Type 2 Diabetes Research Upcoming wave of hormone-based therapies
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doi: 10.1111/bpa.12402 [DOI] [PMC free article] [PubMed] [Google Scholar] 69

Recent Developments In February 2026 , Pfizer announced positive Phase 2b trial results for its ultra-long-acting injectable GLP-1 (PF-08653944), demonstrating significant weight loss with monthly dosing

Lessons From GLP-1/Glucagon Co-Agonists in Clinical Development The first GLP-1/glucagon co-agonist to advance to human clinical trials was cotadutide (MEDI0832)
A market can show strong starts while long-term continuation remains fragile
The overall inflated cost adds to limitation of access to these drugs in resource poor nations (124)
