mechanism of action of glp 1 receptor agonist GLP-1 [25] Current Insights, Advantages and Challenges

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas

This is particularly important, considering that Pfizer NYSE: PFE recently discontinued its oral GLP-1 treatment because of these issues

DOI: 10.1016/j.drugalcdep.2024.112424,

brought about an increase in blood glucose over a 90 minute period

19 In the study, the researchers used a large electronic health record database to conduct a nationwide retrospective cohort study to assess the association of semaglutide with the incidence and recurrence of suicidal ideation compared with non-GLP1R agonist anti-obesity medications in individuals with overweight or obesity