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What the SURPASS clinical trials tell us about this combination The strongest evidence for combining metformin and tirzepatide comes from the SURPASS clinical trial program, a series of large, randomized trials that studied tirzepatide across thousands of patients

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Early effects may be mild, but a more noticeable appetite suppression typically occurs as the dose increases

Anyone with specific metabolic health concerns should consult with a healthcare provider about appropriate options, which may include prescription medications where clinically indicated

This product contains garcinia cambogia extract and studies show that it does not cause rebound effects after discontinuation of the treatment