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These changes result from the direct effect of GLP-1RAs on proinflammatory cytokines production in monocytes/macrophages as it blocks NF-B, and lowers the formation of pro-inflammatory M1 macrophages

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The GLP-1 Revolution: Harnessing the Power of a Miracle Hormone for Optimal Health - Kindle edition by Starks, Dawn

A 2025 study presented at ENDO (the Endocrine Society's annual meeting) confirmed that approximately 40% of weight lost from semaglutide comes from lean mass, with women and older adults at higher risk