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The evolution of the GLP-1RA class to include an oral agent could facilitate the use of these agents earlier in the diabetes treatment cascade owing to wider acceptance from patients and healthcare professionals

Encourages preservation of lean muscle mass
Hypothyroidism slows metabolism and makes weight loss harder, but GLP-1 receptor agonists like semaglutide can still be effective when thyroid hormone is optimized
Liraglutide was approved without a CVOT (Cardiovascular Outcome Trial) because authorities accepted the results from the LEADER study, designed for superiority
