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doi: 10.1016/j.ahj.2018.03.030 17 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al

In contrast to mice with adipose-specific loss of Gipr [589,807], mice with Nestin Cre-mediated neuronal loss of Gipr [795], or with deletion of Gipr specifically in inhibitory GABAergic neurons [581,966], show decreased body weight and fat mass when fed with a HFD, and this is paralleled by decreased food intake without changes in energy expenditure
The once-weekly injection form was approved by the FDA in 2017 for the treatment of type 2 diabetes
