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This loss of elasticity may result in hanging or sagging skin that can feel uncomfortable or make clothes fit poorly

Phase 2 : Overweight individuals with a BMI greater than 30, individuals with uncontrolled hypertension, kidney disease, or heart failure

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Some patients report that a single, larger weekly dose can lead to a peak in side effects that is challenging to manage

Naltrexone was originally developed to treat opioid and alcohol dependence
