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Starting Dose : 2.5 mg once weekly for four weeks
Long-term metformin use has been associated with vitamin B12 deficiency and worsening neuropathy (2)
However, application of APLs in MS may be a double-edged sword
10.1038/s41582-024-00988-2 60 JastreboffA
These include the ghrelin-LEAP2 system and the activity of the GHSR, including its constitutive activity
