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They showed that while the fasting and post-prandial GLP-1 levels in the pre-RYGB surgery patients were lower than in lean controls, the post-prandial GLP-1 levels became higher post-RYGB, whereas fasting GLP-1 levels did not [22]

Clinical data from the SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events with semaglutide, independent of weight loss

After treatment initiation with liraglutide 3.0 mg, it is recommended that, if a patient has not lost at least 4% of their baseline body weight after 16 weeks, the treatment should be discontinued because it is unlikely that significant weight loss will be achieved with the medication after this time point [21]

These achieve substantially greater LDL reductions than the modest 17% decreases observed with GLP-1 receptor agonists

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