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Indeed, nodose GLP-1R lentivirus-mediated knockdown increases postprandial glycemia 128 , and Glp1r Phox2b/ mice, which exhibit selective knockout of GLP-1R in the nodose ganglia, midbrain, and hindbrain, exhibit increased fasting levels of glucose, both highlighting a role for GLP-1 vagal afferent signaling in mediating glucose homeostasis 127

Two of the main incretins are GLP-1 and GIP which work along with insulin, glucagon, and somatostatin in helping to closely regulate blood glucose levels

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Exenatide extended-release (ER) , taken weekly: FDA-approved under the brand name Bydureon to treat type 2 diabetes