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Differentiation GLP-1 and its analogues have been shown to modulate adipogenic and osteogenic differentiation in various hMSC populations, influencing both lipid metabolism and bone formation through distinct signaling pathways

5 They are associated with numerous chronic diseases and represent significant contributors to both morbidity and mortality

Although the FLOW trial and the secondary analysis of the SELECT trial have demonstrated important kidney benefits of semaglutide, the kidney-protective effects of other GLP-1 receptor agonists are less well known, as there have not been prospective trials with kidney outcomes, and it is unclear whether the benefits of these medications are a class effect or are medication specific

Side effects with current GLP-1 drugs are attributed to the triggering of alternative pathways