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Description

In addition to its effects on insulin and glucagon, GLP-1RAs work on the brain for an anorexigenic effect by promoting feelings of satiety and modulating energy homeostasis

Abstract Purpose of Review The pharmacologic management of type 2 diabetes prioritises sodium-glucose cotransporter 2 (SGLT-2) inhibitors or glucagon-like peptide 1 (GLP-1) receptor agonists for their demonstrated cardiovascular benefits in individuals with atherosclerotic cardiovascular disease or multiple cardiovascular risk factors, chronic kidney disease, and heart failure

The combined effects of these mechanisms of action make GLP-1 an effective treatment for type 2 diabetes and obesity, with ongoing studies exploring its broader therapeutic potential

With the food industry being tied to population growth over time, reductions in obesity-related mortality will be a net positive, says Mike Blommer, a food and beverage data specialist at Capital One