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Semaglutide can influence how your body handles fluid balance, but the relationship between GLP-1 therapy and water retention is more nuanced than simple yes or no

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Methods Adults with T2D treated with 2 glucose-lowering agents who initiated GLP-1 RAs or basal insulin from 2010 to 2019 were propensity-score matched (1:1) and followed until October 2021 (intention-to-treat [ITT])

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